Sigma Anti-bonding Calcium Carbonate

SAC in a Nutshell

SAC (Sigma Antibonding Calcium Carbonate) is the only true ionic calcium delivery system that provides calcium in free ionic state, which is the only physiologically active form of calcium in our body. Normally, calcium from diet and supplements enters our body in the protein-bound form and therefore, cannot trigger the same physiological responses as SAC. Resolving calcium deficiency better than protein-bound calcium, SAC triggers ionic-calcium-sensitive physiological responses that counteract the root cause of diseases and brings natural healing reactions of our body from cellular to the systemic level.

The Invention of New Calcium Carbonate

Sigma Anti-bonding Calcium Carbonate (SAC-CaCO3)

SAC is the world’s first calcium-ion-delivery-system, which safely and effectively elevates the level of calcium-ion concentration in our blood. By utilizing a very weak chemical bonding, namely sigma anti-bonding, to calcium carbonate molecules, Calcium & Bone Health Institute of Canada (CBHI) invented new calcium carbonate, which maintains loosely held calcium ion to its carbonate group. The anti-bonding makes the molecules exhibit electrical charge and attract water molecules via hydrogen bonding. Making sigma anti-bonding stable at room temperature was, in itself, a technological breakthrough after ten years of R&D.

The weak chemical bonding of SAC makes calcium ions easily detached and passively absorbed into our system through stomach lining as ions via diffusion and osmotic pressure, not requiring digestion, vitamin D, nor peptides for absorption makes SAC a passive transporter.

Due to the body’s natural sensitivity to fluctuations of serum plasma ionic calcium level, a minimal elevation of ionic calcium concentration achieved by SAC can trigger hormonal responses, such as the release of TSH and calcitonin to activate bone-building osteoblasts. SAC utilizes ionic calcium as a signaling agent to trigger our body’s self-healing responses to reverse calcification from cellular to systemic level, causing domino effects of healing processes to rebuild our health. SAC’s healing pathway is genuinely unique.

"SAC is the world's first safe calcium-ion delivery system administered directly into our body in oral form.
SAC triggers
healing mechanisms no other calcium supplementation can achieve"

What is Sigma Anti-bonding?

Anti-bonding orbitals are essentially the “opposite” of bonding orbitals. They are formed when atomic orbitals combine in ways that lead to predominantly destructive interference.

The key feature of anti-bonding orbitals is that the molecular orbitals have higher energy than the corresponding atomic orbitals. Thus, the molecule has higher energy than the separated atoms (atoms separated by a large distance) and the atoms would prefer to be in the lower atomic state.

Anytime two atomic orbitals combine to give a lower-energy bonding orbital, an analogous higher energy anti-bonding orbital is also formed. The figure depicts this simple bond/anti-bond molecular orbital diagram that we had for hydrogen. The figure also shows that electrons (in this case) completely fill the bonding orbital and leave the anti-bonding orbital empty. SAC calcium’s sigma anti-bonding keeps the calcium atoms in the molecule very loose and unstable. Our innovative technology locks calcium atoms in place until it is released in our body.

SAC's new bio-material is based on calcium carbonate derived from small oyster shells. A highly advanced process formulates it to maintain positive charges (2+) by altering the bonding structure, namely sigma anti-bonding. The molecule's positive charges attract water molecules to cluster around it, making it incredibly water-soluble and allowing direct and passive absorption into the body.

SAC Calcium is directly absorbed because of its anti-bonding positive charge and is immediately bio-available. SAC bypasses active transport delivery that requires digestion with peptides and vitamin D, a complicated process that leaves absorbed calcium far less bio-available.

Unique Physical Properties of SAC Calcium

The SAC calcium carbonate molecule's electrical charge interacts with the hydrogen bonding of water molecules; an open bottle of SAC evaporates calcium together with water molecules and crystalize with CO in the air.

"SAC is 200x more soluble in water compared to calcium carbonate and 3x more reactive in a chemical reaction."

Unique Passive Absorption of SAC

Active Transport of Regular Calcium

Regular calcium intake from diet or supplements needs strong stomach acid with peptides and vitamin D3 to digest and be absorbed in small intestines as protein-bound calcium, which is not readily utilized with aging because of a sedentary lifestyle, hormonal changes, and poor diet. Inactive calcium's various side effects include kidney stones, blood vessel calcification, stroke, heart attack, etc. If not all, calcium supplements fall in this category and may aggravate body-wide calcification, which is known to be one of many major causes of degenerative diseases.

Passive Transport of SAC Calcium

Unlike regular calcium intake, no Vitamin D3 and peptides are needed for absorption. SAC diffuses passively through digestive tract cell linings (mucosa) as ions, not requiring physiological energy from our body and readily available for immediate use.

Ionic calcium is immediately utilized to bring calcium homeostasis :

  1. · Corrects calcium signaling
  2. · Reduces cellular oxidative stress
  3. · Restores mitochondrial function
  4. · Triggers decalcification

Unique Passive Absorption of SAC

About 5 to 7.6 mg of SAC solution is mixed with 500ml of water for optimum absorption as ionic calcium. SAC is taken in an empty stomach and is completely absorbed within 30 minutes through diffusion and osmotic pressure. Although it is in a small intake amount, a slight elevation of ionic calcium in the blood is enough to trigger TSH (stimulating thyroid hormone) to initiate strong bone-building osteoblasts. SAC's cascading effects on our body's physiological functions also activate inactive protein-bound calcium in our blood to boost further and maintain good bone health.

SAC is the First Calcium-ion-delivery-system

SAC can help build and support strong bones while promoting average bone mass. SAC also plays an essential role in other functions such as nerve transmission and muscular function. Unlike other electrically neutral calcium supplements that require Active Transport, SAC calcium’s Passive Transport brings complete calcium absorption without the need for Vitamin D, peptide, or other agents.

Inside our cells, SAC calcium quickly breaks down to yield calcium ions, which are absorbed into capillaries and triggers our body’s natural bone formation process.

Physiological Effects of SAC

After intake, SAC’s effect lasts about four hours in our body, initially raising the serum ionic calcium concentration to a higher yet safe level to trigger various physiological functions before bringing down the serum ionic calcium concentration down to the average physiological level.

While ionic calcium level is elevated, bone-building osteoblast with osteoclastic activity is triggered to raise the bone turnover rate, repairing and rebuilding bones. This process also activates idle protein-bound calcium, releasing both ionic calcium and protein, further fueling bone-building and clearing body-wide calcification. Ionic calcium also aids cellular metabolism, releasing more ATP (adenosine triphosphate) and raising body temperature. As kidneys try to excrete excess ionic calcium through urination, an urge to urinate within an hour of taking SAC is experienced, which is both healthy and normal, indicating that SAC is working.

"A long term, follow up study done in Denmark for 35,000 people revealed that the people with strong bones in their 50’s lived 11.6 years longer.
YET, in Canada, 49% of infants are born with calcium deficiency. Only 70% recover after breastfeeding. Calcium deficiency during pregnancy and infancy leads to serious health issues.

Bone Loss Leads to 150+ Degenerative Diseases

Bone health is directly related to our overall health. Emptier bone characterized by osteoporosis or osteopenia indicates not only a higher risk of fracture but also a greater chance of developing degenerative diseases. Why? Because emptying bones cause calcification in both cellular and systemic levels, causing cellular communications mayhem by disrupting calcium signaling.

Calcium ions in the blood are so vital that the body cannot permit it to fluctuate. Therefore, even a slight increase in the concentration of ionized calcium in the blood triggers the bone building process to take excess calcium into bones. Utilizing this process is by far the most effective and safe way to support strong bones since it follows the body’s natural bone building mechanism. Thisamazing effect of SAC was observed in this animal clinical trial through the bone break test where SAC ‘treated’ bone displayed almost 100x bonebuilding power compared to regular calcium carbonate.

Promising Animal Clinical Trials

The importance of SAC goes beyond the stronger bone-building. Although most of our body’s calcium is stored in bone, the tiny amount that circulates in your bloodstream is disproportionately vital to good health. About half of this circulating serum calcium (50%) is “ionized”, which means it carries electrical charges and these calcium ions (Ca2+) are the only physiologically active form that can be recognized by our body and responsible for numerous functions of our body such as the firing of muscle and nerve cells, promoting blood clotting, preventing the depletion of bone mass, securing proper cellular functions by preserving calcium signaling, etc. As we age, this vital ionic calcium homeostasis is disrupted as our bone breaks down and calcifies trillions of cells. SAC can restore this fragile calcium homeostasis and gives our body a chance to fight back the onset of 150+ degenerative diseases that are thought to be caused by calcium displacement.

Osteoporosis Reversed under SAC

The effects of Sigma Anti-bonding Molecule Calcium Carbonate on bone turnover and calcium balance in ovariectomized rats are studied. The study revealed that the induced osteoporosis was wholly reversed with SAC. Osteocalcin, estradiol, eosinophil, CTx and BMD level were elevated with SAC, indicating that optimal bone health is indeed restored.
Values are mean ± SD for five rats. Means with different superscript letters are significantly different at p<0.05 by Duncan’s multiple range tests.


Human Bone Density Clinical Case under SAC (CBHI Canada Conducted BMD Increase Trial for +1000 Patients under SAC)

CBHI (Calcium & Bone Health Institute of Canada) utilized the Health Canada-approved ultrasound bone densitometer by BeamMed™ to measure and compare BMD data of more than a thousand patients. Over 90% of the patients experienced increased bone density.


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